Neffy Nasal Spray: Everything You Need to Know About Neffy in the UK
Anaphylaxis, a severe and potentially life-threatening allergic reaction, traditionally requires immediate intramuscular injection of adrenaline using an Adrenaline Auto-Injector (AAI).
Recently approved by both the FDA and EMA, Neffy nasal spray (also known as Eurneffy in Europe) offers an innovative, needle-free alternative.
Anticipated to arrive in the UK late 2025, initially only the 2mg dose
Neffy is expected to assist significantly with anaphylaxis treatment.
What is Neffy?
Neffy is a novel, nasal-delivered adrenaline device designed specifically for individuals experiencing anaphylactic reactions.
Developed by ARS Pharmaceuticals, this needle-free nasal spray represents a significant advancement over traditional AAIs. Neffy (epinephrine) is indicated for the emergency treatment of type I allergic reactions, including anaphylaxis, in adults and pediatric patients aged 4 years and older who weigh at least 15 kg.
Licenses in different countries will vary. Currently approved for individuals weighing at least 30kg (typically around 10 years of age), a lower-dose (1mg) version for patients weighing 15kg and above is anticipated.
Advantages of Neffy Nasal Spray Over Traditional AAIs
Needle-Free Administration
One of Neffy’s most significant benefits is eliminating the anxiety and discomfort associated with needle injections. This makes Neffy especially valuable for children and individuals with needle phobia, enhancing compliance and confidence in managing allergic emergencies.
Ease of Use
Neffy’s nasal spray device is intuitively designed for rapid, uncomplicated administration. This user-friendly feature enables quick action during stressful allergic episodes, significantly reducing delays in administering life-saving adrenaline.
Portability and Stability
Neffy’s compact nasal spray device is easier to carry and manage compared to traditional, sometimes bulky AAI devices.
Importantly.
Neffy is expected to have an extended shelf life and greater stability even after exposure to higher environmental temperatures, addressing common concerns related to the storage and efficacy of AAIs.
How Does Adrenaline administered by Neffy Work?
Adrenaline (epinephrine) is a hormone naturally produced by the body. During anaphylaxis, administering adrenaline rapidly counteracts severe symptoms by:
Increasing heart rate and blood flow
Improving heart muscle contractions
Opening the airways
Reducing swelling and hives
It may help stabilise effector cells such as mast cells and basophils.
Neffy delivers adrenaline through nasal absorption, quickly entering the bloodstream to provide systemic effects comparable to traditional intramuscular injections.
Clinical Evidence Supporting Neffy’s Efficacy
Neffy’s approval by regulatory bodies such as the FDA and EMA was based on robust clinical data.
Neffy’s approval is based on clinical pharmacology studies demonstrating that the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of Neffy are comparable to those of established intramuscular epinephrine injection products, such as EpiPen, with similar systemic exposure and hemodynamic responses (pulse rate and systolic blood pressure) in both healthy adults and patients with type I allergy.
A phase 1 crossover study in healthy subjects showed that Neffy 2 mg produced peak plasma epinephrine levels bracketed by those of EpiPen and manual IM injection, and resulted in comparable or greater increases in pharmacodynamic parameters (pulse rate, blood pressure) relative to injection products. In pediatric patients (4–17 years, ≥15 kg), a single dose of Neffy (1 mg for 15–<30 kg, 2 mg for ≥30 kg) produced PK/PD responses within the adult range, supporting extrapolation of efficacy to this population.
A phase 3 open-label study in pediatric food allergy patients demonstrated that Neffy successfully treated oral food challenge–induced anaphylaxis symptoms, with a median symptom resolution time of 16 minutes and no need for a second dose in the initial reaction. Adverse events were consistent with known epinephrine effects, including tremor and nasal erythema.
The FDA label specifies dosing as one spray of Neffy 2 mg for patients ≥30 kg and one spray of Neffy 1 mg for patients 15–<30 kg, with a second dose permitted after 5 minutes if symptoms persist. The safety and effectiveness in patients <4 years or <15 kg have not been established.
For those seeking an in-depth allergy evaluation, oral food and drug challenges offer a safe, controlled environment to assess potential allergic reactions and treatment readiness.
How to Administer Neffy Nasal Spray
Neffy is administered through the nostril. If symptoms persist or worsen after the first dose, a second dose may be administered in the same nostril, differing from standard AAI guidance, where alternating injection sites is recommended.
Clear instructions provided with the device further simplify the process, ensuring proper administration during an emergency. The device should not be primed (or a dose may be lost).
If this is your first time exploring allergy treatments for your child, consider consulting a paediatric allergy specialist in London to create a personalised care plan.
Potential Side Effects of Neffy
Like all medical treatments, Neffy has associated side effects, although they are typically mild and short-lived. Common side effects include:
Nasal irritation, itchiness, or congestion
Throat irritation
Headache or dizziness
Fatigue or jitteriness
Abdominal discomfort or nausea
Sneezing or runny nose
Despite these side effects, the benefits of rapid adrenaline delivery during anaphylaxis substantially outweigh any temporary discomfort.
Availability of Neffy in the UK
Currently, Neffy nasal spray has regulatory approval from both the FDA and EMA. Its introduction into the UK market and subsequent integration into NHS care systems is anticipated to be finalised by 2025. Until Neffy becomes widely available, patients must continue to rely on conventional AAIs and follow existing allergy treatment pathways in London.
Managing Allergies Beyond Neffy
While Neffy offers an exciting new treatment option, long-term allergy management is essential. Regular allergy reviews, specialist follow-ups, and proactive care strategies such as oral immunotherapy can improve quality of life and reduce allergic reactivity over time.
Parents managing multiple allergies may find these guides helpful:
For an even broader overview, the London Allergies blog provides coverage of common conditions, triggers, and treatment advancements.
Conclusion
Neffy nasal spray represents a significant step forward in allergy emergency care, offering a needle-free and easy-to-use alternative for treating anaphylaxis.
With comparable effectiveness to traditional auto-injectors and added convenience for everyday use, it holds particular promise for children, schools, and individuals managing severe allergies.
While its NHS rollout is still pending, understanding how Neffy fits into broader allergy treatment plans is vital.
Until it becomes widely available in the UK, ongoing support through allergy testing, specialist appointments, and personalised treatment strategies remains essential.
For those seeking up-to-date information or tailored care, London Allergy Consultants continues to provide trusted guidance for every stage of allergy management.
Frequently Asked Questions
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Neffy is expected to be available in the UK market late 2025, subject to NHS approval and regulatory integration.
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Yes, children weighing at least 30kg (approximately 10 years and older) can use the currently approved 2mg dose.
A 1mg dose suitable for younger children is also anticipated later in the year.
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Clinical trials indicate that Neffy achieves comparable adrenaline blood levels and physiological effects as traditional AAI’s.
The use in everyday settings will be assessed once it becomes available on the market.
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Neffy provides a reliable alternative for suitable individuals, but traditional AAIs will remain essential, especially for children weighing under 30kg or patients unable to use a nasal administered product, e.g. nasal polyps, atresia, neurodiversity…
Worried About Allergies? Let’s Help You Get Answers
If your child is showing signs of a food, pollen, or skin allergy, early diagnosis is key. At London Allergy Consultants, our expert team provides trusted, evidence-based care tailored to your child’s needs. From testing to treatment plans, we guide you every step of the way. We are happy to assess babies (infants), toddlers, young children, adolescents and young adults with allergies.
London Allergy Consultants
London Allergy Consultants is a leading UK centre for diagnosing and treating food and airborne allergies in children and young people.
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Explore Neffy nasal spray, the innovative needle-free adrenaline device for anaphylaxis. Discover its UK availability, benefits, usage guidance, and expert insights.